吴建国，1981年生，安徽池州人，博士，教授，博士生导师，福建省A类高层次人才。“十四五”重点研发计划首席科学家，国家杰出青年科学基金、优秀青年科学基金以及教育部霍英东基金获得者。2004年至2010年师从谢联辉院士和李毅教授攻读博士学位，2010年至2016年在北京大澳门挂牌393444cm命科学澳门挂牌393444cm李毅教授与清华大澳门挂牌393444cm命澳门挂牌393444cm戚益军教授实验室从事博士后研究工作，并荣获北京大学-清华大澳门挂牌393444cm命科学联合中心“优秀博士后”及罗氏“优秀博士后”奖。长期致力于水稻抗病毒及病毒致病机理研究，在Developmental Cell、Nature Plants（高被引论文）、Nature Communications、Molecular Plant（3篇）、National Science Review、Journal of Integrative Plant Biology（高被引论文）、eLife、Plant Physiology（2篇）、Plant Biotechnology Journal（3篇）、PLoS Pathogens（3篇） 和 Molecular Plant-Microbe Interactions 等国内外顶尖期刊发表高水平论文50余篇，申请国内外专利20余项。其学术论文累计被引用超过2700次。获福建省自然科学一等奖（2024）、中国农学会青年科技奖（2021）、中国植物病理学会青年植物病理学家奖（2016）、福建青年科技奖（2020）、福建运盛青年科技奖（2022）、福州市青年科技奖（2020）、福建省五四青年奖章（2015）、福建省高校教师教学创新大赛一等奖（2024）、全国高校教师教学创新大赛三等奖（2024）、严家显最高奖教金（2018）及福建农林大学优秀教师奖（2019）。此外，2012年获福建省“优秀博士论文二等奖”，并先后入选福建省高校杰出青年科研人才培育计划（2013）、福建省青年拔尖人才（2014）、福建省新世纪优秀人才计划（2017）及福建省高校领军人才计划（2018）。现任农林生物安全全国重点实验室副主任、福建农林大学遗传改良中心主任、媒介病毒研究中心执行主任；兼任中国植物病理学会植物与病原互作委员会秘书长、中国植物病理学会青年学术委员会副主任、中国微生物学会病毒学专业委员会委员、中国昆虫学会媒介昆虫与病原互作专委会委员等。担任SCIENCE CHINA Life Sciences、Journal of Integrative Plant Biology (JIPB) 和《激光生物学报》等学术期刊编委和常务编委。
研究方向和兴趣：
1. 基于RNA沉默的水稻抗病毒和病毒致病机制；
2. 水稻抗病毒、抗虫资源的筛选和抗病虫基因的克。
3. 病毒与宿主的相互作用以及病毒对宿主发育的影响；
4. 植物病毒的反向病原学。
基金支持：
2020年国家杰出青年基金项目；
2019年国家自然基金海峡联合基金重点项目；
2018年福建省高校领军人才-拔尖人才项目；
2017年国家优秀青年基金项目；
2017年国家自然基金面上项目；
2012年国家自然基金面上项目。
发表论文：
1. Jing Zou, Shuai Zhang, Ying Chen, Chun He, Xin Pan, Yimin Zhang, Jianwei Xu, Lijia Zheng, Hongxin Guan, Ming Wu, Dongqi Xie, Yinghua Ji, Xianyang Fang, Yi Li, Shou-wei Ding, Xiaofeng Fang, Shanshan Zhao, Jianguo Wu. A plant bunyaviral protein disrupts SERRATE phase separation to modulate microRNA biogenesis during viralpathogenesis.Nature Communications, 2025, DOI:10.1038/s41467-025-61528-0.
2. Yuansheng Wu, Shanshan Zhao, Na Liu, Fengling Wu, Shiting Huang, Dongyuan Li, Baiyang Li，Yutong Miao, Hongxin Guan, Ming Wu, Shuai Zhang, Yi Li, Jie Zhang and Jianguo Wu. A virulence protein activates SERK4 and degrades RNA polymerase IV protein to suppress rice anti-viral immunity. Developmental Cell, 2025 https://doi.org/10.1016/j.devcel.2025.04.017.
3. Shaoyuan Lü, Zhihong Zhu, Xiyuan Yu, Chaoyi Dong, Jiamin Cao, Zhiyi Zhang, Hongfei Liu, Qiong Hu, Jie Hu, Qun Hu, Shanshan Zhao, Jianguo Wu, Shuai Zhang. Phenylpropanoid Metabolites Mediate Antiviral Defense and Vector Resistance in Rice Infected With RRSV, RGSV, and SRBSDV. Plant, Cell & Environment, 2025, 1–15, https://doi.org/10.1111/pce.15592.
4. Wang Lu ?, Wu Yuansheng ?, Zhang Jialin ?, Li Shanshan, Junjie Ren, Yang Liyuan, Ye Wenyang, Ying Xinrong, Liu Jiajun, Liu Xinzhou, Salem M S, Ding Chengqiang, Shen Jianguo, Wu Zujian, Wu Jianguo *, Zhao Shanshan *. Spatial Regulation of Rice Leaf Morphology by miRNA-Target Complexes During Viral Infection. Plant, Cell & Environment，2025，DOI: 10.1111.PCE.15460.
5. Juan Huang, Juan Du, Yan Liu, Lu Lu, Yanzhuo Xu, Jianfei Shi, Qing Liu, Qi Li, Yang Liu, Yaqiu Chen, Meng Du, Yiming Zhao, Liangxiao Huo, Weiran Wang, Chenxi Ding, Liya Wei, Jianguo Wu, Yao-Wu Yuan, Jinfeng Chen, Ruixi Li, Feng Cui, Xiaoming Zhang. RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum–chloroplast membrane contact sites. Nature Communications, 2025, 16 (1), 1953.
6. Zhang S., Gan P., Xie H., Li C., Tang T., Hu Q., Zhu Z., Zhang Z., Zhang J., Zhu Y., Hu Q., Hu J., Guan H., Zhao S., Wu J. Virulence effectors encoded in the rice yellow dwarf phytoplasma genome participate in pathogenesis. Plant Physiology, 2024, 7: kiae601.
7. Lü S., Yu X., Wu X., Hu Q., Zhu X., Wu M., Hu Q., Zhao S., Hu J., Wu J., Zhang S. The microRNA399d-PHOSPHATE2 module alters rice sensitivity to rice ragged stunt virus by manipulating phosphate uptake. Plant Physiology, 2024, 27: kiae517.
8. Han X., Li S., Zeng Q., Sun P., Wu D., Wu J., Yu X., Lai Z., Milne R.J., Kang Z., Xie K., Li G. Genetic engineering including genome editing for broad-spectrum disease resistance in crops. Plant Communication, 2024, Nov 19:101195. doi: 10.1016/j.xplc.2024.101195.
9. Zhu L.-J., Zhu Y., Zou C., Su L.-Y., Zhang C.-T., Wang C., Bai Y.-N., Chen B., Li R., Wu Q., Ding S.-W., Wu J., Han Y.-H. New persistent plant RNA virus carries mutations to weaken viral suppression of antiviral RNA interference. Molecular Plant Pathology, 2024, 25(10): e70020.
10. Tan C., Wu J., Men S. Distinctive outlook into the mechanism of resistance to rice blast. Phytopathology Research, 2024, 6: 36.
11. Zhang B., Zhang X., Li W., Pan D., Ma B., Duan X., Dong C., Wang L., Zhao M., Zhao S., Zhang S., Wu J. A resource for functional investigation of miRNAs in rice responses to viral infection. Plant Biotechnology Journal, 2024, 22: 3380–3382.
12. Xie H., Gan P., Lü S., Tang T., Li C., Chen C., Guan X., Zhu Z., Ye Y., Huang X., Zhao S., Hu J., Zhang S., Wu J. Development of marker-free transgenic rice exhibiting stable and enhanced resistance to Rice ragged stunt virus and Rice grassy stunt virus via RNA interference. Plant Biotechnology Journal, 2024, 22: 2327–2329.
13. Ye Y., Wang Y., Zou L., Wu X., Zhang F., Chen C., Xiong S., Liang B., Zhu Z., Wu W., Zhang S., Wu J., Hu J. Identification and candidate analysis of a new brown planthopper resistance locus in an Indian landrace of rice, paedai kalibungga. Molecular Breeding, 2024, 44(7): 45.
14. Wu J., Zhang Y., Li F., Zhang X., Ye J., Wei T., Li Z., Tao X., Cui F., Wang X., Zhang L., Yan F., Li S., Liu Y., Li D., Zhou X., Li Y. Plant virology in the 21st century in China: Recent advances and future directions. Journal of Integrative Plant Biology, 2024, 66(3): 579–622. （高被引论文）
15. Wu Y., Liu N., Zheng C., Li D., Li S., Wu J., Zhao S. Insights into the complexity and functionality of plant virus protein phosphorylation. Molecular Plant-Microbe Interactions, 2024, 37(8): 598–610.
16. Wu X., Liu H., Lian B., Jiang X., Chen C., Tang T., Ding X., Hu J., Zhao S., Zhang S., Wu J. Genome-wide analysis of epigenetic and transcriptional changes in the pathogenesis of RGSV in rice. Frontiers in Plant Science, 2023, 13: 1090794.
17. Yan W., Zhu Y., Liu W., Zou C., Jia B., Chen Z.-Q., Han Y., Wu J., Yang D.-L., Zhang Z., Xie L., Chen B., Li R., Ding S.-W., Wu Q., Guo Z. Discovery of aphid-transmitted rice tiller inhibition virus from native plants through metagenomic sequencing. PLoS Pathogens, 2023, 19(3): e1011238.
18. Wu J., Yang G., Zhao S., Zhang S., Qin B., Zhu Y., Xie H., Chang Q., Wang L., Hu J., Zhang C., Zhang B., Zeng D., Zhang J., Huang X., Qian Q., Ding S.-W., Li Y. Current rice production is highly vulnerable to insect-borne viral diseases. National Science Review, 2022, 9(9): nwac131.
19. Zhao S., Wu J. Rapid and specific purification of Argonaute-small RNA complexes from rice for slicer activity. Methods in Molecular Biology, 2022, 2400: 139–147.
20. Zhao S., Wu Y., Wu J. Arms race between rice and viruses: a review of viral proteins and plant factors. Current Opinion in Virology, 2021, 47: 38–44.
21. Wang L., Xie H., Zheng X., Chen J., Zhang S., Wu J. Recent advances and emerging trends in antiviral defence networking in rice. The Crop Journal, 2021, 9(3): 553–563.
22. Zhang S., Wu X., Xie H., Zhao S., Wu J. Multifaceted roles of RNA polymerase IV in plant growth and development. Journal of Experimental Botany, 2020, 71(19): 5725–5732.
23. Zhang C., Wei Y., Xu L., Wu K., Yang L., Shi C., Yang G., Chen D., Yu F., Xie Q., Ding S.-W., Wu J. A bunyavirus-inducible ubiquitin ligase targets RNA polymerase IV for degradation during viral pathogenesis in rice. Molecular Plant, 2020, 13(6): 836–850. （封面论文）
24. Xu L., Yuan K., Yuan M., Meng X., Chen M., Wu J., Li J., Qi Y. Regulation of rice tillering by RNA-directed DNA methylation at miniature inverted-repeat transposable elements. Molecular Plant, 2020, 13(6): 851–863.
25. Zhang C., Chen D., Yang G., Yu X., Wu J. Rice stripe mosaic virus-encoded P4 is a weak suppressor of viral RNA silencing and is required for disease symptom development. Molecular Plant-Microbe Interactions, 2020, 33(3): 412–422. （封面论文）
26. Qin J., Wang C., Wang L., Zhao S., Wu J. Defense and counter-defense in rice–virus interactions. Phytopathology Research, 2019, 1: 34.
27. Zhang B., Li W., Pan D., Ma B., Duan X., Dong C., Wang L., Zhao M., Zhao S., Zhang S., Wu J. Roles of small RNAs in virus-plant interactions. Viruses, 2019, 11(9): 827.
28. Yao S., Yang Z., Yang R., Huang Y., Guo G., Kong X., Lan Y., Zhou T., Wang H., Wang W., Cao X., Wu J., Li Y. Transcriptional regulation of miR528 by OsSPL9 orchestrates antiviral response in rice. Molecular Plant, 2019, 12(8): 1114–1122. （封面论文）
29. Zheng L., Zhang C., Wu J., Li Y. Detecting the interaction of double-stranded RNA binding protein, viral protein and primary miRNA transcript by co-immunoprecipitation in planta. Bio-protocol, 2018, 8(9): 2840.
30. Zhang C., Shi C., Chen D., Wu J.* Rice ragged stunt virus propagation and infection on rice plants. Bio-protocol, 2018, 8(20): 3060.
31. Wang Z., Xia Y., Lin S., Wang Y., Guo B., Song X., Ding S., Zheng L., Feng R., Chen S., Bao Y., Sheng C., Zhang X., Wu J., Niu D., Jin H., Zhao H. Osa-miR164a targets OsNAC60 and negatively regulates rice immunity against the blast fungus Magnaporthe oryzae. The Plant Journal, 2018, 95(4): 584–597.
32. Wu J., Yang R., Yang Z., Yao S., Zhao S., Wang Y., Li P., Song X., Jin L., Zhou T., Lan Y., Xie L., Zhou X., Chu C., Qi Y., Cao X., Li Y. ROS accumulation and antiviral defence control by microRNA528 in rice. Nature Plants, 2017, 3(16): 203. （高被引论文）
33. Zhao S., Hong W., Wu J., Wang Y., Ji S., Zhu S., Wei C., Zhang J., Li Y.* A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection. eLife, 2017, 6: e27529.
34. Zheng L., Zhang C., Shi C., Yang Z., Wang Y., Zhou T., Sun F., Wang H., Zhao S., Qin Q., Qiao R., Ding Z., Wei C., Xie L., Wu J., Li Y. Rice stripe virus NS3 protein regulates primary miRNA processing through association with the miRNA biogenesis factor OsDRB1 and facilitates virus infection in rice. PLoS Pathogens, 2017, 13(10): e1006662.
35. Zhang C., Ding Z., Wu K., Yang L., Li Y., Yang Z., Shi S., Liu X., Zhao S., Yang Z., Wang Y., Zheng L., Wei J., Du Z., Zhang A., Miao H., Li Y., Wu Z., Wu J. Suppression of jasmonic acid-mediated defense by viral-inducible microRNA319 facilitates virus infection in rice. Molecular Plant, 2016, 9: 1372–1384.
36. Jin L., Qin Q., Wang Y., Pu Y., Liu L., Wen X., Ji S., Wu J., Wei C., Ding B., Li Y.* Rice dwarf virus P2 protein hijacks auxin signaling by directly targeting the rice OsIAA10 protein, enhancing viral infection and disease development. PLoS Pathogens, 2016, 12(9): e1005847.
37. Wu J., Yang Z., Wang Y., Zheng L., Ye R., Ji Y., Zhao S., Ji S., Liu R., Xu L., Zheng H., Zhou Y., Zhang X., Cao X., Xie L., Wu Z., Qi Y., Li Y.* Viral-inducible Argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA. eLife, 2015, 4: e05733.
38. Zhang C., Liu X., Wu K., Zheng L., Ding Z., Li F., Zou P., Yang L., Wu J., Wu Z. Rice grassy stunt virus nonstructural protein P5 serves as a viral suppressor of RNA silencing and interacts with nonstructural protein P3. Archives of Virology, 2015, 160(11): 2769–2779.
39. Zhang C., Wu Z., Li Y., Wu J. Biogenesis, function and applications of virus-derived small RNAs in plants. Frontiers in Microbiology, 2015, 6: 1237.
40. Zheng L., Du Z., Lin C., Mao Q., Wu K., Wu J., Wei T., Wu Z., Xie L. Rice stripe tenuivirus P2 may recruit or manipulate nucleolar functions through an interaction with fibrillarin to promote virus systemic movement. Molecular Plant Pathology, 2015, 16(9): 921–935.
41. Yang L., Du Z., Gao F., Wu K., Xie L., Li Y., Wu Z., Wu J. Transcriptome profiling confirmed correlations between symptoms and transcriptional changes in RDV-infected rice and revealed nucleolus as a possible target of RDV manipulation. Virology Journal, 2014, 11: 81.
42. Seo J.-K., Wu J., Lii Y., Li Y., Jin H. Contribution of small RNA pathway components in plant immunity. Molecular Plant-Microbe Interactions, 2013, 26(6): 617–625.
43. Du P., Wu J., Zhang J., Zhao S., Zheng H., Gao G., Wei L., Li Y.* Viral infection induces expression of novel phased microRNAs from conserved cellular microRNA precursors. PLoS Pathogens, 2011, 7(8): e1002176.
44. Du Z., Xiao D., Wu J., Jia D., Yuan Z., Liu Y., Hu L., Han Z., Wei T., Lin Q., Wu Z., Xie L. P2 of Rice stripe virus (RSV) interacts with OsSGS3 and is a silencing suppressor. Molecular Plant Pathology, 2011, 12(8): 808–814.
45. Wu J., Wang C., Du Z., Cai L., Hu M., Wu Z., Li Y., Xie L. Identification of Pns12 as the second silencing suppressor of rice gall dwarf virus. Science China Life Sciences, 2011, 54(3): 201–208. （封面论文）
46. Wu J., Du Z., Wang C., Cai L., Hu M., Lin Q., Wu Z., Li Y., Xie L. Identification of Pns6, a putative movement protein of RRSV, as a silencing suppressor. Virology Journal, 2010, 7: 335.
47. Wu Z., Wu J., Adkins S., Xie L., Li W. Rice ragged stunt virus segment S6-encoded nonstructural protein Pns6 complements cell-to-cell movement of tobacco mosaic virus-based chimeric virus. Virus Research, 2010, 152: 176–179.
48. Wang C., Gao F., Wu J., Dai J., Wei C., Li Y.* Arabidopsis putative deacetylase AtSRT2 regulates basal defense by suppressing PAD4, EDS5 and SID2 expression. Plant and Cell Physiology, 2010, 51(8): 1291–1299.
49. Guo J., Ren F., Wang Y., Li S., Gao Z., Wang X., Ning H., Wu J., Li Y., Wang Z., Chim S.M., Xu J., Chang Z.* miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression. Journal of Bone and Mineral Research, 2012, 27(7): 1607–1618.
E-mail：wujianguo81@126.com
